Scientific Basis
The scientific material underpinning the method consists of four papers produced at the Fundeni Clinical Hospital in Bucharest. All of them carry the dermatology department heading and are signed by named teams of authors.
The first dermatology department of the Fundeni Hospital in Bucharest was established in 1978. The four papers below were written there, all of them carrying the heading Fundeni Clinical Hospital, Dermatology Department, Bucharest, Romania.
Scientific papers — Fundeni Hospital
The papers are reproduced in full below, in the form in which they were typed at the time. The originals are kept at the practice.
- Kozak P. A New Aethyopathogenic Approach of the Therapy Applied in the Chronic Discoid Lupus Erythematosus and Ichtyosis. Fundeni Clinical Hospital, Dermatology Department, Bucharest. Typescript. Details:Sets out the framework of the method: the enzymatic metabolism of certain amino acids, glycolysis, serum proteins, acid-base equilibrium, the distribution of trace elements, haemostasis disturbances and the dietary regimen as part of the treatment scheme.
- Ionescu G, Kozak P, Rotaru A, Rarinca C, Hulea S, Teofil D, Brad I, Popa M, Predescu M. Serum Proteins, Trace Elements, Hemostasis Parameters, Food Antigens and Related Variables Involved in the Pathogenesis of Chronic Cutaneous Lupus Erythematosus. Fundeni Clinical Hospital, Dermatology Department, Bucharest. Typescript. Details:A preliminary study on 28 cases of chronic cutaneous lupus erythematosus.
- Kozak P, Rarinca C, Rotaru A, Ionescu G, Brad I. Acid-Base Status and Glycolytic Parameters in Chronic Discoid Lupus Erythematosus and Ichtyosis Patients. Fundeni Clinical Hospital, Dermatology Department, Bucharest. Typescript. Details:Measurements in 19 patients with chronic discoid lupus erythematosus and 11 patients with ichthyosis.
- Kozak P, Rotaru A, Ionescu G, Rarinca C, Hulea S, Brad I. Observations cliniques et morphopathologiques concernant l’efficacité du traitement Kozak chez les malades souffrant d’ichtyose. Fundeni Clinical Hospital, Dermatology Department, Bucharest. Typescript, in French. Details:Clinical and morphopathological observations in 16 patients with ichthyosis.
The method in the international medical literature
The method also appears in international medical journals, in three publications from 1983 and 1984.
- Katz SI, Bauer EA, Lazarus GS, McGuire JS, Briggaman RA, Sidica V. Mr. Kozak’s regime for epidermolysis bullosa. Journal of the American Academy of Dermatology, 1983;8(4):565–567. DOI 10.1016/S0190-9622(83)80068-1.Details:A letter to the editor, signed by six American dermatologists.
- Wodinsky HB. Cost analysis of the Kozak protocol as used in an Ontario hospital in the treatment of children with epidermolysis bullosa. Canadian Medical Association Journal, 1984;130(6):715–717. PMID 6697279.Details:A cost analysis for nine children with epidermolysis bullosa treated under the Kozak protocol at the Hospital for Sick Children in Toronto, in the 1982–1983 fiscal year.
- Ramsay CA. Cost analysis of the Kozak protocol in the treatment of epidermolysis bullosa. Canadian Medical Association Journal, 1984;130(12):1526, 1528. PMID 6428728.Details:A letter to the editor, on the cost analysis above.